Spend 3 nights in Medellin and 2 nights in Cartagena, then enjoy a 7-night cruise from Cartanega to Barranquilla, followed by 3 nights in Panama City.

1. Day 1
   Mon, Dec 01, 2025

   MEDELL''N. Arrive in the city of Medell''n, the second largest city in Colombia. Named the most innovative city in the world by the Urban Land Institute in 2013, this fascinating city combines modern conveniences with colonial history. Check into your hotel and enjoy your first night in this unique city.
2. Day 2
   Tue, Dec 02, 2025

   MEDELL''N. Though the city was once known for violent campaigns, Medell''n has undergone impressive social transformations, and you will get to examine the drastic differences as you tour one of the city'''s neighborhoods. Once a setting of political corruption'''s influence on the city, the neighborhood has now been elevated to a place of strengthened community, music and art. See this vibrant atmosphere for yourself on your guided tour. (B)
3. Day 3
   Wed, Dec 03, 2025

   MEDELL''N. The region's ideal climate and soil conditions, combined with the skill and passion of local farmers, make for a unique and delicious coffee experience, which you can learn about and enjoy for yourself during a guided excursion. Before the majority of coffee farms moved south, the state of Antioquia was where coffee growth in Colombia first begin, planting the seed of tradition and culture strongly in this region. The coffee beans grown in Medell''n are known for their rich and complex flavor profiles, with notes of dark chocolate, caramel, and berries. This delightful coffee is also certified by organizations such as the Rainforest Alliance, which ensures that the coffee is grown in a sustainable and environmentally friendly way. (B)
4. Day 4
   Thu, Dec 04, 2025

   MEDELL''N ''' CARTAGENA. In the morning, check out of your hotel and fly to Cartagena, the beautiful capital of the Bolivar region located on Colombia'''s Caribbean coast. Take the day to delight in the beautiful coastal city of Cartagena. Many Spaniards flocked to this location when they heard tales of gold found in the tombs of indigenous leaders, expanding this small port into a thriving city. As you tour the city, you may witness iconic landmarks such as the Catedral de Cartagena or the stone walls built to protect the city from the plundering of pirates, although they did not stop Sir Francis Drake from holding the city for ransom in 1586. (B)
5. Day 5
   Fri, Dec 05, 2025

   CARTAGENA. Start your day by exploring the incredible UNESCO-designated San Felipe Castle, the fortress that defended Cartagena from French and British attacks. As you walk through Cartagena, learn more about emeralds and the impact of these precious gemstones on the city'''s history. Alternatively, visit the Gold Museum, which features ancient gold artifacts from the indigenous cultures found in this region. You will also visit the Caribbean Naval Museum. Follow the story of this fascinating country and its incredible naval history from pre-Hispanic times until the present. (B)
6. Day 6
   Sat, Dec 06, 2025

   CARTAGENA ''' EMBARKATION. Before checking out of your hotel, tour the famous vaults of Cartagena. These vaults have gone through many transformations ''' from being Spanish headquarters to a prison for those seeking independence from Spain to the art galleries, restaurants and shops you can witness today. After settling into your stateroom, enjoy a tour through the breathtaking neighborhood of Getsemani. With the vibrant colors of the homes and street art as well as the mouthwatering local delicacies that can be found throughout the area, this historic neighborhood will delight all your senses. In the evening, watch the sun set on Cartagena as we set sail on your magical Magdalena River journey (B, D)
7. Day 7
   Sun, Dec 07, 2025

   GAMBOTE (PALENQUE) ''' CALAMAR. In the morning, experience the town of Palenque, the first '''free town''' in the Americas. Founded by those who fled a life of slavery during colonial times, the spirit and appearance of this town has been preserved through time. In 1713, the Spanish crown issued a Royal Decree that officially freed the people of Palenque from slavery. Immerse yourself in the town'''s deeply rooted culture and traditions, which are so distinct that UNESCO declared Palenque to be a Masterpiece of the Oral and Intangible Heritage of Humanity. An important piece of their heritage is the music and rhythmic style that was developed in this city, which you will enjoy during a special performance by local musicians. Later in the day, visit Calamar. Located at the entrance of the Canal del Dique, this town was first settled in 1840. Witness historic sites such as the Iglesia de la Inmaculada Conception as you tour this beautiful destination by paola (a bicycle taxi for two). (B, L, D)
8. Day 8
   Mon, Dec 08, 2025

   SANTA BARBARA DE PINTO - MOMPOX. Spend your morning in Santa Barbara de Pinto, located on the banks of the Mompox arm of the Magdalena River. Enjoy a walking tour through this traditional town, where you may see local landmarks such as the Santa Barbara Church and enjoy intricate hand-made crafts created in the town. In the afternoon, arrive at the island town of Mompox, where you will be welcomed with open arms and lively music during an exclusive jazz performance played by local musicians. (B,L,D)
9. Day 9
   Tue, Dec 09, 2025

   MOMPOX. A town frozen in time, Mompox embodies the appearance of what many villages looked like during colonial times. Founded in 1540, this remote village became an important Spanish trading post. Some Spaniards found Mompox to be a haven for keeping gold and other treasure protected from the pirates that pillaged coastal cities like Cartagena, and with this precious metal and the work of skilled artisans from Spain came beautifully crafted artifacts. Since then, the town has become famous for its incredible filigree jewelry, which you can learn more about during your tour of this town. While visiting the largest inland island in Latin America, journey through the beautiful wetlands, exploring the massive lake that is home to a variety of flora and fauna native to the region, with opportunities to birdwatch at sunrise, early morning and sunset. In either the morning or the afternoon, you can choose to take a stroll through this storied town on a guided walking tour. With stunning colonial churches, breathtaking nature surrounding the town, and delicious local delights such as capa cheese and butifarra, Mompox is sure to be a highlight of your journey along the magnificent Magdalena River. (B, L, D)
10. Day 10
    Wed, Dec 10, 2025

    MOMPOX ''' EL BANCO. Bid farewell to Mompox before embarking on a scenic cruise down one of the most breathtaking stretches of the Magdalena River ''' a picturesque part of the La Mojana region ''' and reaching the town of El Banco, nestled at the intersection of the Magdalena and C''sar rivers. Founded in a strategic location for both the native people and the Spaniards, the town was repeatedly destroyed in their struggles and then rebuilt atop its ashes. In 1749, a freed black slave named Jos'' Domingo Ortiz led a group of settlers to this special location, carrying with him a statue of the Virgin Mary, staking this place as their new home. Because of this connection, the Virgin of Candelaria ''' a special invocation of the Virgin Mary ''' is specially venerated in this region. Embark on a guided walking tour of this incredible destination and learn more about its history as the birthplace of cumbia, an iconic genre of music and dance that has now been popularized around the world. What began as a courtship dance practiced by African slaves later incorporated American steps and European and African instruments has become a worldwide sensation, which is especially popular in the Andean region of Colombia. In the evening, enjoy an exclusive cumbia performance by locals. (B, L, D)
11. Day 11
    Thu, Dec 11, 2025

    MAGANGUE. Witness the sights, hear the bird calls, and watch the wildlife around you as spend the day docked near Magangue. Immerse yourself in the presence of Colombian nature surrounding this city on a birdwatching tour, giving you a unique opportunity to see birds only found in this specific part of the country. (B,L,D)
12. Day 12
    Fri, Dec 12, 2025

    NEUVA VENECIA ''' BARRANQUILLA. In the morning, visit the Floating Village of Nueva Venecia. A charming town filled with inviting locals, Nueva Venecia, or '''New Venice,''' can only be navigated by boat. With its beautiful colonial houses, vivid architecture and local sanctuary protecting the native flora and fauna, this town highlights the beauty and warmth of Colombia. Witness its splendor as you tour the village. While here, explore this village and learn more about the lives of its people during a guided tour. Enjoy the traditional crafts and art that is on display, learn about the techniques the fishermen of Nueva Venecia use, and taste the local delicacies as you embrace this village and its unique culture. Later in the day, venture to the beautiful seaside city of Barranquilla, a vibrant destination home to notable musicians, writers and artists. Immerse yourself in the warmth and culture of the city'''s atmosphere as you venture through this magnificent location, where you may visit famous landmarks such as the bocas de cenizas, the point at which the magical Magdalena River meets the breathtaking Caribbean Sea, and the '''Carnaval''' Museum, which showcases the unique history of this incredible festival. In the evening, enjoy an exclusive '''Carnaval''' celebration just for AmaWaterways guests as we bring the full traditional experience to our guests all-year round. (B,L,D)
13. Day 13
    Sat, Dec 13, 2025

    BARRANQUILLA ''' DISEMBARKATION ''' PANAMA. Disembark your ship and fly to Panama City, famous for the canal that separates North and South America. Start your Panama journey in Panama Casco Viejo. Located in the middle of skyscrapers, this charming UNESCO World Heritage Site still conserves its initial mystical flavor. Casco Viejo preserves the first institutions and buildings that laid the foundation for the Panama that we know today. Explore the city walls that were built to protect the city from pirate attacks. Walk through Plaza de Francia, a beautiful public square that pays homage to France'''s role in building the iconic Panama Canal, and Plaza Carlos V, named for the most powerful monarch in Europe during the 16th century. Take in the stunning la compa''ia architecture prominent in this historic area of the city, showcased in breathtaking buildings such as the Catedral Bas''lica Santa Mar''a la Antigua de Panam''. Immerse yourself in the vivid colors of Casco Viejo as you make your way to your hotel, where you will be staying during your time in this incredible city. (B)
14. Day 14
    Sun, Dec 14, 2025

    PANAMA. Discover one of the world'''s engineering marvels, the Panama Canal, on this full-day excursion. Opened in 1914 after more than 30 years of construction, the canal revolutionized international trade by shortening voyages between the Pacific Ocean and the Caribbean Sea. Visit the Panama Canal Administration Building, a historic landmark, and learn about the legacy of Chief Engineer George W. Goethals and the canal'''s impact on global commerce. Then, embark on an intimate boat expedition on Gatun Lake, once the world'''s largest artificial lake. Surrounded by lush rainforest, the lake serves as a vibrant habitat for the local wildlife, including many species of tropical birds and monkeys. After enjoying a delicious lunch featuring regional cuisine at a local resort, continue to the Miraflores Visitor Center for a private tour, where you'll dive deeper into the canal'''s history, operation, and biodiversity and discover why it continues to be a vital waterway for international commerce. (B, L)
15. Day 15
    Mon, Dec 15, 2025

    PANAMA. Be dazzled by a breathtaking rainforest near the Chagres National Park, taking in the amazing scenery that surrounds you. Navigate the Gatun Lake through this magical jungle before continuing to an Ember'' village. The Ember'' are a riverine people of Panama, historically building their houses along banks of rivers. These people came from another location when Gatun Lake was created, finding a new home next to this bridge of water. Savor a traditional Ember'' tasting experience that is sure to delight your taste buds. Immerse yourself in the ritual dances, local music, handcrafts and more as you experience and embrace this unique culture. (B)
16. Day 16
    Tue, Dec 16, 2025

    PANAMA. Bid Panama farewell and prepare for your flight home. (B)