Located where Switzerland, Germany and France meet, Basel reflects a fascinating blend of traditions. The city straddles the Rhine at the river's farthest navigable point, and an alluring cluster of old-town buildings huddles along the riverbank. Around Market Square, guild houses recall Gothic, Renaissance and baroque splendor; the red-sandstone Rathaus, or Town Hall, is the centerpiece. More than 40 museums of art and culture lend modern polish to its history-rich streets. And there is no more refined way to sample it all than over cheese fondue or croissants.

A delightful blend of old and new, Basel is Switzerland's best-kept secret. Amid the medieval Old Town, cobblestone streets are lined with pastel-colored buildings that date back to the 15th century. In the heart of the city lies the Jean Tinguely–designed Carnival Fountain. Its mechanical sculptures are in constant motion, seemingly conversing with each other like the mime artists and performers who graced the stage of the old city theater that once stood in the same spot.

Breisach is a gateway to the fabled Black Forest region, built on a basalt rock outcropping in the Rhine plain. It is located in one of the warmest parts of Germany, across the river from French Alsace, famous for its wine growing. But Breisach, too, can boast about its wine: it is home to Europe's largest cellars, with a storage capacity of more than 160 million liters. The most prominent landmark of Breisach is the Romanesque-Gothic St. Stephen's Cathedral, built between the 12th and 13th centuries. Its two towers are visible from throughout the city and from the Rhine.

The largest port on the Upper Rhine, Strasbourg is the cultural center of France's Alsace region. Thanks to its location at the border of France and Germany, it boasts a convivial mix of cultural influences. The well-preserved old town is enclosed on all sides by the little Ill River, with sites so compact that it is easy to explore the "island” on foot. And there is plenty to explore: cobblestone streets lined with wooden houses and intersected by picturesque canals. Indulging in Alsatian café culture is central to any visit here; enjoy coffee and cake amid lovely half-timbered houses.

Blending tradition and modernity, Karlsruhe is one of southwest Germany's cultural gems. Founded as the Grand Duchy of Baden during the early-18th century, the city is home to the majestic Karlsruhe Palace, from which the city's streets span forming a distinctive circular layout. Innovation is ingrained in the city's DNA; it was the chosen destination to establish the world-renowned Karlsruhe Institute of Technology in 2009. Numerous museums, theaters and galleries are popular sights to explore, as well as the peaceful green spaces that offer a serene escape from city life.

Straddling the Main River, Frankfurt has been nicknamed "Mainhattan” for its skyline that resembles that of Manhattan. It is a major financial center and a rich hub of culture, history and architecture. No fewer than nine museums line the Main embankment, covering everything from art to film to ethnology. In the Roman Hill district, Frankfurt's town hall spreads out over 11 conjoined patrician houses. Emperors were crowned in the Gothic St. Bartholomew's Cathedral, and remnants from Roman settlements are on exhibit in the city's Archaeological Garden.

Marktheidenfeld is a picturesque town situated in the Lower Franconia region of Bavaria and boasts a rich heritage that dates back to medieval times. Well-preserved, half-timbered houses line quaint streets and in its heart lies a bustling Marktplatz, or market square, that exudes character and a vibrant atmosphere. Local restaurants serve traditional hearty Bavarian fare, including delicious dishes such as Schweinshaxe (pork knuckle), Kaiserschmarrn (scrambled caramelized pancake) and the more commonly known bratwurst.

Surrounded by Franconian vineyards, Würzburg was heavily damaged during World War II, but has since been completely restored. This prestigious university city is a jewel of baroque architecture. Its most pristine example of pomp and glory is the great Bishops' Residenz palace, built in 1744 for the prince-bishop; his unwavering support of artists is evidenced by the sweeping staircase and magnificent ceiling frescoes by Tiepolo. Other landmarks include the medieval, statue-lined Old Main Bridge and Marienberg Fortress, originally a Celtic hill fort and later residence of the bishops. The city remains a major wine-making center, hosting Germany's oldest and largest vineyard.

Founded in 902, Bamberg remains a medieval-looking city known for its symphony orchestra and rauchbier, specialty smoked beer. The city's winding streets are filled with baroque patrician houses and are home to the stunning 11th-century Cathedral of Holy Roman Emperor Heinrich II, housing his tomb and that of Pope Clement II. Bamberg is especially noted for its Altes Rathaus, or Old Town Hall, situated on a twin-arched bridge over the Regnitz River, and for the old bishop's houses: the 16th-century Alte Hofhaltung (Old Court) and 17th-century Neue Residenz (New Residence).

The second-largest city in Bavaria, Nuremberg is filled with traditional half-timbered houses and Gothic churches with intricate spires. Although nearly destroyed during World War II, the remaining medieval city walls stretch some three miles and feature original gateways and 80 original watchtowers. Nuremberg is well known historically for its metal and toy craftsmanship. But it is infamous for its role in World War II, first as the site of Zeppelin Field's Nazi rallies and later as the site of the war crimes trials at the Palace of Justice that captured the attention of a generation.

Bid farewell to your fellow guests and journey home. Or spend more time exploring, perhaps joining one of our extensions.